Copulation-induced antinociception in female rats is blocked by atosiban, an oxytocin receptor antagonist
P Gómora-Arrati, O Gonzalez-Flores… - Hormones and …, 2019 - Elsevier
Aims We hypothesized that copulation-induced temporary anti-nociception in female rats is
mediated by the activation of central and/or peripheral oxytocin receptors. To test this
hypothesis, we assessed the effects of intraperitoneal (ip), intrathecal (it), and intra-
cerebroventricular (icv) administration of an oxytocin receptor antagonist (atosiban), on
copulation-induced temporary anti-nociception in estrous rats. Main methods The treatment
groups were ovariectomized rats pre-treated subcutaneously (sc) with 10 μg of estradiol …
mediated by the activation of central and/or peripheral oxytocin receptors. To test this
hypothesis, we assessed the effects of intraperitoneal (ip), intrathecal (it), and intra-
cerebroventricular (icv) administration of an oxytocin receptor antagonist (atosiban), on
copulation-induced temporary anti-nociception in estrous rats. Main methods The treatment
groups were ovariectomized rats pre-treated subcutaneously (sc) with 10 μg of estradiol …
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