[HTML][HTML] Decreased expression of the mitochondrial BCAT protein correlates with improved patient survival in IDH‐WT gliomas
ME Conway, J Hull, M El Hindy, SC Taylor… - Brain …, 2016 - ncbi.nlm.nih.gov
Brain Pathology, 2016•ncbi.nlm.nih.gov
Gliomas represent 43% of all solid intracranial tumors, of which glioblastomas have the
poorest prognosis. For the first time, we report increased expression of the human
mitochondrial branched-chain aminotransferase protein (hBCATm)(P50. 036) in
glioblastomas carrying wild-type isocitrate dehydrogenase (IDH-WT) genes. Moreover, in
IDH-WT gliomas we identify low BCATm as a positive prognostic marker linked to improved
patient overall survival. Recently, Tönjes et al showed that increased gene expression of the …
poorest prognosis. For the first time, we report increased expression of the human
mitochondrial branched-chain aminotransferase protein (hBCATm)(P50. 036) in
glioblastomas carrying wild-type isocitrate dehydrogenase (IDH-WT) genes. Moreover, in
IDH-WT gliomas we identify low BCATm as a positive prognostic marker linked to improved
patient overall survival. Recently, Tönjes et al showed that increased gene expression of the …
Gliomas represent 43% of all solid intracranial tumors, of which glioblastomas have the poorest prognosis. For the first time, we report increased expression of the human mitochondrial branched-chain aminotransferase protein (hBCATm)(P50. 036) in glioblastomas carrying wild-type isocitrate dehydrogenase (IDH-WT) genes. Moreover, in IDH-WT gliomas we identify low BCATm as a positive prognostic marker linked to improved patient overall survival. Recently, Tönjes et al showed that increased gene expression of the branched chain amino-acid transaminase 1 (BCAT1—gene encoding cytoplasmic protein hBCATc) promotes cell proliferation
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