Degradation of CREB-binding protein and modulation of type I interferon induction by the zinc finger motif of the porcine reproductive and respiratory syndrome virus …
Non-structural protein (nsp) 1 of PRRS virus is a viral antagonist for type I interferons (IFNs),
and in cells expressing nsp1, CREB-binding protein (CBP) is degraded. nsp1 is auto-
processed into nsp1α and nsp1β subunits and in the present study we show that the nsp1α
subunit was responsible for CBP degradation. The nsp1α subunit contains three distinct
functional motifs; a papain-like cysteine protease α (PCPα) motif, an N-terminal zinc finger
motif (ZF1), and a newly reported C-terminal zinc finger motif (ZF2). To study the structure …
and in cells expressing nsp1, CREB-binding protein (CBP) is degraded. nsp1 is auto-
processed into nsp1α and nsp1β subunits and in the present study we show that the nsp1α
subunit was responsible for CBP degradation. The nsp1α subunit contains three distinct
functional motifs; a papain-like cysteine protease α (PCPα) motif, an N-terminal zinc finger
motif (ZF1), and a newly reported C-terminal zinc finger motif (ZF2). To study the structure …
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