Dermal uptake and excretion of 14C-toluene diisocyante (TDI) and 14C-methylene diphenyl diisocyanate (MDI) in male rats. Clinical signs and histopathology …
HD Hoffmann, E Leibold, C Ehnes, E Fabian… - Toxicology letters, 2010 - Elsevier
Polyurethanes (PU) are polymers made with diisocyanates such as MDI (4, 4′-methylene
diphenyl diisocyanate) and TDI (2, 4-toluene diisocyanate and 2, 6-toluene diisocyanate).
Investigations have been undertaken with MDI and TDI to assess dermal uptake and
resulting systemic exposure. Absorption, distribution and excretion of MDI was studied in
rats using a single dermal administration of 14C-MDI dissolved in acetone at nominal
165mg/kg body weight and 15mg/kg bw (4.0 and 0.4 mg/cm2) and intradermal injection of …
diphenyl diisocyanate) and TDI (2, 4-toluene diisocyanate and 2, 6-toluene diisocyanate).
Investigations have been undertaken with MDI and TDI to assess dermal uptake and
resulting systemic exposure. Absorption, distribution and excretion of MDI was studied in
rats using a single dermal administration of 14C-MDI dissolved in acetone at nominal
165mg/kg body weight and 15mg/kg bw (4.0 and 0.4 mg/cm2) and intradermal injection of …
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