Development of a nanomedicine-loaded hydrogel for sustained delivery of an angiogenic growth factor to the ischaemic myocardium
The 5-year mortality rate for heart failure borders on 50%. The main cause is an ischaemic
cardiac event where blood supply to the tissue is lost and cell death occurs. Over time, this
damage spreads and the heart is no longer able to pump efficiently. Increasing
vascularisation of the affected area has been shown to reduce patient symptoms. The
growth factors required to do this have short half-lives making development of an efficacious
therapy difficult. Herein, the angiogenic growth factor Vascular Endothelial Growth Factor …
cardiac event where blood supply to the tissue is lost and cell death occurs. Over time, this
damage spreads and the heart is no longer able to pump efficiently. Increasing
vascularisation of the affected area has been shown to reduce patient symptoms. The
growth factors required to do this have short half-lives making development of an efficacious
therapy difficult. Herein, the angiogenic growth factor Vascular Endothelial Growth Factor …
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