Different neuropeptsde Y receptor subtypes in rat and rabbit vas deferens
HN Doods, J Krause - European journal of pharmacology, 1991 - Elsevier
HN Doods, J Krause
European journal of pharmacology, 1991•ElsevierPrejunctional neuropeptide Y (NPY) receptors that inhibit the contractions evoked in rat and
rabbit vas deferons by field stimulation were investigated by using NPY,[Leu 31, Pro 34]
NPY and the fragments, NPY-(13–36) and NPY-(18–36). NPY, and especially [Leu 31 Pro
34] NPY, were more potent agonists on the twitch response of the rabbit vas deferens. In
contrast the NPY C-terminal fragments, NPY-(13–36) and NPY-(18–36), inhibited the twitch
response at lower concentrations in the rat vas deferens. These results indicate that distinct …
rabbit vas deferons by field stimulation were investigated by using NPY,[Leu 31, Pro 34]
NPY and the fragments, NPY-(13–36) and NPY-(18–36). NPY, and especially [Leu 31 Pro
34] NPY, were more potent agonists on the twitch response of the rabbit vas deferens. In
contrast the NPY C-terminal fragments, NPY-(13–36) and NPY-(18–36), inhibited the twitch
response at lower concentrations in the rat vas deferens. These results indicate that distinct …
Abstract
Prejunctional neuropeptide Y (NPY) receptors that inhibit the contractions evoked in rat and rabbit vas deferons by field stimulation were investigated by using NPY, [Leu31,Pro34]NPY and the fragments, NPY-(13–36) and NPY-(18–36). NPY, and especially [Leu31Pro34]NPY, were more potent agonists on the twitch response of the rabbit vas deferens. In contrast the NPY C-terminal fragments, NPY-(13–36) and NPY-(18–36), inhibited the twitch response at lower concentrations in the rat vas deferens. These results indicate that distinct NPY receptor subtypes mediate the biological effect in these two tissues. We suggest that prejunctional receptors in the rat vas deferens are of the Y2-subtype and those in rabbit vas deferens of the Y1-subtype.
Elsevier
以上显示的是最相近的搜索结果。 查看全部搜索结果