Distribution of antinociceptive adenosine A1 receptors in the spinal cord dorsal horn, and relationship to primary afferents and neuronal subpopulations
G Schulte, B Robertson, BB Fredholm, GE DeLander… - Neuroscience, 2003 - Elsevier
Adenosine can reduce pain and allodynia in animals and man, probably via spinal
adenosine A1 receptors. In the present study, we investigate the distribution of the
adenosine A1 receptor in the rat spinal cord dorsal horn using immunohistochemistry, in situ
hybridization, radioligand binding, and confocal microscopy. In the lumbar cord dorsal horn,
dense immunoreactivity was seen in the inner part of lamina II. This was unaltered by dorsal
root section or thoracic cord hemisection. Confocal microscopy of the dorsal horn revealed …
adenosine A1 receptors. In the present study, we investigate the distribution of the
adenosine A1 receptor in the rat spinal cord dorsal horn using immunohistochemistry, in situ
hybridization, radioligand binding, and confocal microscopy. In the lumbar cord dorsal horn,
dense immunoreactivity was seen in the inner part of lamina II. This was unaltered by dorsal
root section or thoracic cord hemisection. Confocal microscopy of the dorsal horn revealed …
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