Does mechanical injury of the peripheral airways play a role in the genesis of COPD in smokers?

J Milic‐Emili - COPD: Journal of Chronic Obstructive Pulmonary …, 2004 - Taylor & Francis
In the present account it is proposed that in smokers the transition from peripheral airway
disease to COPD is characterized by three sequential stages: Stage I, during which the
closing volume eventually exceeds the functional residual capacity; Stage II, during which
tidal expiratory flow limitation (EFL) is eventually exhibited; and Stage III, during which
dynamic hyperinflation progressively increases leading to dyspnea and exercise limitation,
which may be considered as markers of overt disease. Presence of airway closure (Stage I) …

[引用][C] Does mechanical injury of the peripheral airways play a role in the genesis of COPD in smokers?

J Milic-Emili - Revue des maladies respiratoires, 2003 - pubmed.ncbi.nlm.nih.gov
[Does mechanical injury of the peripheral airways play a role in the genesis of COPD in
smokers?] [Does mechanical injury of the peripheral airways play a role in the genesis of
COPD in smokers?] … Smoking / adverse effects* …
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