Does topical voriconazole trigger dysplastic changes on the ocular surface?
M Palamar, S Egrilmez, SG Yilmaz, SH Polat… - Journal of …, 2015 - Taylor & Francis
M Palamar, S Egrilmez, SG Yilmaz, SH Polat, OU Gunduz
Journal of Chemotherapy, 2015•Taylor & FrancisPurpose: Systemic voriconazole treatment was reported to cause photosensitivity and
related cutaneous malignancies. The aim of this report is to demonstrate a graft-related
Candida endophthalmitis case that developed ocular surface dysplastic changes after
receiving topical 1% voriconazole treatment. Methods: Full ocular examination,
photography, and in vivo confocal microscopy examination (Rostock Cornea Module/HRT II,
Heidelberg, Germany) were performed. Results: A 73-year-old male with graft-related …
related cutaneous malignancies. The aim of this report is to demonstrate a graft-related
Candida endophthalmitis case that developed ocular surface dysplastic changes after
receiving topical 1% voriconazole treatment. Methods: Full ocular examination,
photography, and in vivo confocal microscopy examination (Rostock Cornea Module/HRT II,
Heidelberg, Germany) were performed. Results: A 73-year-old male with graft-related …
Abstract
Purpose:
Systemic voriconazole treatment was reported to cause photosensitivity and related cutaneous malignancies. The aim of this report is to demonstrate a graft-related Candida endophthalmitis case that developed ocular surface dysplastic changes after receiving topical 1% voriconazole treatment.
Methods:
Full ocular examination, photography, and in vivo confocal microscopy examination (Rostock Cornea Module/HRT II, Heidelberg, Germany) were performed.
Results:
A 73-year-old male with graft-related Candida endophthalmitis that was on topical 1% voriconazole for 4 months developed a whitish gelatinous lesion on the cornea originating from the nasal limbus. In vivo confocal microscopy examination revealed mild dysplastic changes in the cornea epithelium.
Conclusion:
Topical voriconazole might trigger neoplastic changes on the ocular surface as reported with systemic use in other sun-exposed parts of the body. Further studies are needed to relate topical use of voriconazole with ocular surface dysplasia.
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