The use of drugs, in Honduras, involves 25% of college students. The most used substances include legal and recreational drugs, such as alcohol. This study aimed to identify the use of drugs and socio-demographic factors in a sample of 260 medical students. RESULTS: Average age of 20 years old, unemployed and religious women, single, with no children. Alcohol was the most consumed drug in the last six months for recreational purposes. The following stimulants were frequently consumed: caffeine, mate herb tea, energetic drinks and Coke. Drugs like marijuana, cocaine, valium and sedatives were used in smaller proportions. The reasons reported by women were: to alleviate tiredness and improve their academic performance. The men's reasons were recreation and to alleviate psychological tension. This research has implications for the development of drugs prevention programs in universities.