Duality of tocopherol isoforms and novel associations with vitamins involved in one-carbon metabolism: results from an elderly sample of the lifelines cohort study
CG Sotomayor, I Minović, ML Eggersdorfer… - Nutrients, 2020 - mdpi.com
CG Sotomayor, I Minović, ML Eggersdorfer, IJ Riphagen, MH de Borst, LH Dekker, IM Nolte…
Nutrients, 2020•mdpi.comWhether the affinity of serum vitamin E with total lipids hampers the appropriate assessment
of its association with age-related risk factors has not been investigated in epidemiological
studies. We aimed to compare linear regression-derived coefficients of the association of
non-indexed and total lipids-indexed vitamin E isoforms with clinical and laboratory
characteristics pertaining to the lipid, metabolic syndrome, and one-carbon metabolism
biological domains. We studied 1429 elderly subjects (non-vitamin supplement users, 60 …
of its association with age-related risk factors has not been investigated in epidemiological
studies. We aimed to compare linear regression-derived coefficients of the association of
non-indexed and total lipids-indexed vitamin E isoforms with clinical and laboratory
characteristics pertaining to the lipid, metabolic syndrome, and one-carbon metabolism
biological domains. We studied 1429 elderly subjects (non-vitamin supplement users, 60 …
Whether the affinity of serum vitamin E with total lipids hampers the appropriate assessment of its association with age-related risk factors has not been investigated in epidemiological studies. We aimed to compare linear regression-derived coefficients of the association of non-indexed and total lipids-indexed vitamin E isoforms with clinical and laboratory characteristics pertaining to the lipid, metabolic syndrome, and one-carbon metabolism biological domains. We studied 1429 elderly subjects (non-vitamin supplement users, 60–75 years old, with low and high socioeconomic status) from the population-based LifeLines Cohort and Biobank Study. We found that the associations of tocopherol isoforms with lipids were inverted in total lipids-indexed analyses, which may be indicative of overcorrection. Irrespective of the methods of standardization, we consistently found positive associations of α-tocopherol with vitamins of the one-carbon metabolism pathway and inverse associations with characteristics related to glucose metabolism. The associations of γ-tocopherol were often opposite to those of α-tocopherol. These data suggest that tocopherol isoforms and one-carbon metabolism are related, with beneficial and adverse associations for α-tocopherol and γ-tocopherol, respectively. Whether tocopherol isoforms, or their interplay, truly affect the one-carbon metabolism pathway remains to be further studied.
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