Dysfunctional renal nitric oxide synthase as a determinant of salt-sensitive hypertension: mechanisms of renal artery endothelial dysfunction and role of endothelin for …
M Barton, I Vos, S Shaw, P Boer… - Journal of the …, 2000 - journals.lww.com
This study investigated the role of renal nitric oxide synthase (NOS), endothelin, and
possible mechanisms of renovascular dysfunction in salt-sensitive hypertension. Salt-
sensitive (DS) and salt-resistant (DR) Dahl rats were treated for 8 wk with high salt diet (4%
NaCl) alone or in combination with the ET A receptor antagonist LU135252 (60 mg/kg per
d). Salt loading markedly increased NOS activity (pmol citrulline/mg protein per min) in renal
cortex and medulla in DR but not in DS rats by 270 and 246%, respectively. Hypertension in …
possible mechanisms of renovascular dysfunction in salt-sensitive hypertension. Salt-
sensitive (DS) and salt-resistant (DR) Dahl rats were treated for 8 wk with high salt diet (4%
NaCl) alone or in combination with the ET A receptor antagonist LU135252 (60 mg/kg per
d). Salt loading markedly increased NOS activity (pmol citrulline/mg protein per min) in renal
cortex and medulla in DR but not in DS rats by 270 and 246%, respectively. Hypertension in …
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