[HTML][HTML] Early antinociception delays edema but does not reduce the magnitude of persistent pain in the formalin test
BK Taylor, AI Basbaum - The Journal of Pain, 2000 - Elsevier
Intraplantar formalin injection produces early (Phase 1, 0-to 5-minute) and late (Phase 2, 15-
plus minutes after injection) nociceptive responses, including painlike behavior and
activation of primary afferents and dorsal horn neurons. Although we and others have
reported that opioid analgesia or local anesthesia during Phase 1 does not reduce the
overall magnitude of behavioral and/or neuronal responses during Phase 2, recent studies
concluded that spinal sensitization during Phase 1 significantly contributes to the magnitude …
plus minutes after injection) nociceptive responses, including painlike behavior and
activation of primary afferents and dorsal horn neurons. Although we and others have
reported that opioid analgesia or local anesthesia during Phase 1 does not reduce the
overall magnitude of behavioral and/or neuronal responses during Phase 2, recent studies
concluded that spinal sensitization during Phase 1 significantly contributes to the magnitude …
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