Acromegaly secondary to extra-pituitary tumors secreting growth hormone releasing
hormone (GHRH) is rarely encountered. We review the literature on ectopic acromegaly and
present the index report of ectopic acromegaly secondary to GHRH secretion from a
mediastinal paraganglioma. Clinical and pathological manifestations and therapeutic
management of 99 patients with ectopic acromegaly are reviewed. Acromegaly secondary to
ectopic GHRH secretion is usually caused by a neuroendocrine tumor in the lung and …

(LH, 8.9 U/l; FSH, 7.9 U/l; estradiol, 177 pg/ml) with regular menstrual cycles. No reduction in
the pulmonary tumor size on CT was noted. The patient underwent a right upper lobecto‑my
with clear tumor margins. A pathological re‑port revealed a typical carcinoid with a mitotic
count of less than 2 mitoses/2 mm2 andabsence of necrosis. Immunostaining was positive
for chromogranin and CD56. Additional staining of the tumor showed high expression of
GHRH and SSTR2 (80% of the cells)(FIGURE 1F and 1G). The concentrations of GH and …