Metformin impairs bile acid homeostasis in ethinylestradiol-induced cholestasis in mice
FA Faradonbeh, II Sa, H Lastuvkova… - Chemico-Biological …, 2021 - Elsevier
… drug, recently demonstrated a reducing effect on bile acids (BA) … present study was to examine
the effect of metformin on BA … flow of bile in an intact liver by increasing biliary secretion of …
the effect of metformin on BA … flow of bile in an intact liver by increasing biliary secretion of …
Hepatoprotection of auraptene from the peels of citrus fruits against 17α-ethinylestradiol-induced cholestasis in mice by activating farnesoid X receptor
J Wang, T Fu, R Dong, C Wang, K Liu, H Sun, X Huo… - Food & Function, 2019 - pubs.rsc.org
… hepatoprotective effect of auraptene, the mRNA levels of bile acid … the decreases in the bile
flow and biliary bile acid output in the … Since the canalicular secretion of bile acids is the rate-…
flow and biliary bile acid output in the … Since the canalicular secretion of bile acids is the rate-…
Galactosylated Pro–Drug of Ursodeoxycholic Acid: Design, Synthesis, Characterization, and Pharmacological Effects in a Rat Model of Estrogen-Induced Cholestasis
F Di Guida, C Pirozzi, S Magliocca… - Molecular …, 2018 - ACS Publications
… responsible for the biliary excretion of amide-conjugated bile salts, … effect highlights UDCAgal
capability to restore the normal biliary bile acid secretion, favoring hepatobiliary secretion …
capability to restore the normal biliary bile acid secretion, favoring hepatobiliary secretion …
[PDF][PDF] Effect of 4-hydroxyandrost-4-ene-3, 17-dione (formestane) on the bile secretion and metabolism of 4-(14) C-cholesterol to bile acids
B Czerny, M Teister, Z Juzyszyn, A Modrzejewski… - Pharmacol …, 2005 - if-pan.krakow.pl
… and bile acid synthesis, intestinal cholesterol absorption, biliary cholesterol secretion and …
HM: Differential effects of 17alpha-ethinylestradiol on the neutral and acidic pathways of …
HM: Differential effects of 17alpha-ethinylestradiol on the neutral and acidic pathways of …
Disturbances of bile acid metabolism in cholestasis
A STIEHL - Clinics in gastroenterology, 1977 - Elsevier
… bile acids lead to an increased urinary excretion of bile acids. As a consequence of the
decreased biliary excretion of bile acids … intestine and therefore less secondary bile acids such as …
decreased biliary excretion of bile acids … intestine and therefore less secondary bile acids such as …
Mechanisms of cholestasis
GA Kullak-Ublick, PJ Meier - Clinics in liver disease, 2000 - Elsevier
… compounds destined for biliary secretion is mediated by … levels in serum and reduced
biliary bile acid secretion 164 … by the solvent action of bile salts within the biliary tree.26, 129 …
biliary bile acid secretion 164 … by the solvent action of bile salts within the biliary tree.26, 129 …
Pyrazinamide induced rat cholestatic liver injury through inhibition of FXR regulatory effect on bile acid synthesis and transport
HL Guo, HM Hassan, Y Zhang, SZ Dong… - Toxicological …, 2016 - academic.oup.com
… Mdr2 is essential for the formation of biliary mixed micelles with bile acids, and for the … biliary
excretion rate of BAs and phospholipids. This effect might be due to stimulate bile secretion …
excretion rate of BAs and phospholipids. This effect might be due to stimulate bile secretion …
Transporter studies with the 3-O-sulfate conjugate of 17α-ethinylestradiol: assessment of human liver drug transporters
YH Han, D Busler, Y Hong, Y Tian, C Chen… - Drug metabolism and …, 2010 - ASPET
… Collectively, the data show that hepatic uptake of EE2-Sul can be mediated by three
transporters (OATP1B1, OATP2B1, and NTCP), whereas biliary excretion of EE2-Sul into bile likely …
transporters (OATP1B1, OATP2B1, and NTCP), whereas biliary excretion of EE2-Sul into bile likely …
Role of AMP-activated protein kinase α1 in 17α-ethinylestradiol-induced cholestasis in rats
X Li, R Liu, L Luo, L Yu, X Chen, L Sun, T Wang… - Archives of …, 2017 - Springer
… effect of CC on the EE-induced impairment of bile acid … effect of Compound C on EE-induced
cholestasis in rat model. a The serum ALP activity and TBA, b bile acid flow rates and biliary …
cholestasis in rat model. a The serum ALP activity and TBA, b bile acid flow rates and biliary …
Bile acid homeostasis paradigm and its connotation with cholestatic liver diseases
… of BA homeostasis, and any deficit in this link could affect the existing homeostasis. …
The blood–biliary barrier is required for bile secretion and is not accompanied by leakage …
The blood–biliary barrier is required for bile secretion and is not accompanied by leakage …