In view of the facts that ginseng has been shown to improve age-related memory deficits and
β-amyloid-related peptides have been suggested to play a significant role in memory
degeneration in the elderly, the present study was carried out to examine the effect of
various ginsenosides on β-amyloid peptides-modulated acetylcholine (ACh) release, a key
neurotransmitter in memory processing, from the hippocampal slices. Addition of β-amyloid
fragment 25-35 (0.01-1 μM) in the superfusion medium suppressed the K+-evoked [3 H] …

In view of the facts that ginseng has been shown to improve age-related memory deficits and
β-amyloid-related peptides have been suggested to play a significant role in memory
degeneration in the elderly. Laboratory experiments were conducted to examine the effect of
various ginsenosides isolated from Panax quinquefolius on β-amyloid peptides-modulated
acetylcholine (ACh) release, a key neurotransmitter in memory processing, from rat
hippocampal slices. Addition of β-amyloid fragment25-35 (0.01-1 µM) in the superfusion …