Effect of intraperitoneally, intravenously and intralesionally administered monoclonal anti-beta-FGF antibodies on rat chondrosarcoma tumor vascularization and …
G Coppola, M Atlas-White, S Katsahambas… - Anticancer …, 1997 - europepmc.org
The growth and vascularization of many tumours has been reported to be associated with
the overexpression of the potent mitogenic and angiogenic polypeptide basic fibroblast
growth factor (beta-FGF). Consequently, it has been proposed that inhibition of beta-FGF
action would prevent the growth of beta-FGF-dependent tumours. In this study, cell culture
assays were established to assess the ability of mouse monoclonal DG-2 anti-beta-FGF
antibodies to inhibit the mitogenic action of beta-FGF in vitro. Following in vitro …
the overexpression of the potent mitogenic and angiogenic polypeptide basic fibroblast
growth factor (beta-FGF). Consequently, it has been proposed that inhibition of beta-FGF
action would prevent the growth of beta-FGF-dependent tumours. In this study, cell culture
assays were established to assess the ability of mouse monoclonal DG-2 anti-beta-FGF
antibodies to inhibit the mitogenic action of beta-FGF in vitro. Following in vitro …
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