[HTML][HTML] Effect of itopride, a new prokinetic, in patients with mild GERD: a pilot study
YS Kim, TH Kim, CS Choi, YW Shon… - World journal of …, 2005 - ncbi.nlm.nih.gov
YS Kim, TH Kim, CS Choi, YW Shon, SW Kim, GS Seo, YH Nah, MG Choi, SC Choi
World journal of gastroenterology: WJG, 2005•ncbi.nlm.nih.govAIM: Itopride is a newly developed prokinetic agent, which enhances gastric motility through
both antidopaminergic and anti-acetylcholinesterasic actions. The importance of
esophageal motor dysfunction in the pathogenesis of gastro-esophageal reflux disease
(GERD) makes it interesting to examine the effect of itopride on esophageal acid exposure.
METHODS: The effect of itopride on esophageal acid reflux variables for 24 h was studied in
26 patients with GERD symptoms, pre-entry total acid exposure time (pH< 4) of more than …
both antidopaminergic and anti-acetylcholinesterasic actions. The importance of
esophageal motor dysfunction in the pathogenesis of gastro-esophageal reflux disease
(GERD) makes it interesting to examine the effect of itopride on esophageal acid exposure.
METHODS: The effect of itopride on esophageal acid reflux variables for 24 h was studied in
26 patients with GERD symptoms, pre-entry total acid exposure time (pH< 4) of more than …
Abstract
AIM: Itopride is a newly developed prokinetic agent, which enhances gastric motility through both antidopaminergic and anti-acetylcholinesterasic actions. The importance of esophageal motor dysfunction in the pathogenesis of gastro-esophageal reflux disease (GERD) makes it interesting to examine the effect of itopride on esophageal acid exposure.
METHODS: The effect of itopride on esophageal acid reflux variables for 24 h was studied in 26 patients with GERD symptoms, pre-entry total acid exposure time (pH< 4) of more than 5% and mild esophagitis (Savary-Miller grades I, II) proven by endoscopy. Ambulatory 24-h pH-metry and symptom assessment were performed after treatments with 150 or 300 mg itopride thrice a day (tid) for 30 d in random order, using an open label method. For evaluating the safety of itopride, blood biochemical laboratory test was performed and the serum prolactin level was also examined before and after treatment.
RESULTS: Total symptom score was significantly decreased after treatment in 150-or 300-mg group. Itopride 300 mg was significantly effective than 150 mg on decreasing the total per cent time with pH< 4, total time with pH< 4 and DeMeester score. No serious adverse effects were observed with administration of itopride in both groups.
CONCLUSION: Itopride 100 mg tid is effective on decreasing pathologic reflux in patient with GERD and therefore it has the potential to be effective in the treatment of this disease.
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