Effect of melatonin supplementation and cross-fostering on renal glutathione system and development of hypertension in spontaneously hypertensive rats
L Siew-Keah, A Sundaram, KNS Sirajudeen… - Journal of physiology …, 2014 - Springer
Antenatal and postnatal environments are hypothesised to influence the development of
hypertension. This study investigates the synergistic effect of cross-fostering and melatonin
supplementation on the development of hypertension and renal glutathione system in
spontaneously hypertensive rats (SHR). In one experiment, 1-day-old male SHR pups were
fostered to either SHR (shr-SHR) or Wistar-Kyoto rats,(shr-WKY). In a concurrent experiment,
SHR dams were given melatonin in drinking water (10 mg/kg body weight) from day 1 of …
hypertension. This study investigates the synergistic effect of cross-fostering and melatonin
supplementation on the development of hypertension and renal glutathione system in
spontaneously hypertensive rats (SHR). In one experiment, 1-day-old male SHR pups were
fostered to either SHR (shr-SHR) or Wistar-Kyoto rats,(shr-WKY). In a concurrent experiment,
SHR dams were given melatonin in drinking water (10 mg/kg body weight) from day 1 of …
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