EFFECT OF TACROLIMUS (FK506) AND SIROLIMUS (RAPAMYCIN) MONO-AND COMBINATION THERAPY IN PROLONGATION OF RENAL ALLOGRAFT …
S Qi, D Xu, J Peng, MD Vu, J Wu, I Bekersky… - …, 2000 - journals.lww.com
Background. Our previous studies confirmed that tacrolimus (FK506) and sirolimus
[rapamycin (RAPA)], in combination, are not antagonistic but are synergistic in the
prolongation of heart and small bowel grafts in the rodent. The aim of this study was to
confirm further the synergistic effect of combined FK506 and RAPA in the more clinically
relevant model, kidney transplantation in monkeys. Methods. A total of 60 male Vervet
monkeys were randomly assigned to 10 groups (n≥ 5). Monkeys with renal allografts were …
[rapamycin (RAPA)], in combination, are not antagonistic but are synergistic in the
prolongation of heart and small bowel grafts in the rodent. The aim of this study was to
confirm further the synergistic effect of combined FK506 and RAPA in the more clinically
relevant model, kidney transplantation in monkeys. Methods. A total of 60 male Vervet
monkeys were randomly assigned to 10 groups (n≥ 5). Monkeys with renal allografts were …
Effect of tacrolimus (FK506) and sirolimus (RAPA) mono-and combination-therapy in prolongation of renal graft survival in the monkey
H Chen, S Qi, D Xu, J Peng, M Vu, W Fitzsimmons… - …, 1998 - journals.lww.com
In vitro, FK506 and RAPA have been reported to be antagonistic. In contrast, our previous
studies proved that the combined use of FK506 and RAPA had a synergistic effect in
prolongation of heart allograft survival in the rat and small bowel allograft survival in the
mouse. The aim of this study was to evaluate the FK506-RAPA combination in the more
clinically relevant model, kidney transplantation in primates. Eight groups of Male Vervet
monkeys (Cercopithecus aethiops), 3-6 kg, received kidney allografts and were treated with …
studies proved that the combined use of FK506 and RAPA had a synergistic effect in
prolongation of heart allograft survival in the rat and small bowel allograft survival in the
mouse. The aim of this study was to evaluate the FK506-RAPA combination in the more
clinically relevant model, kidney transplantation in primates. Eight groups of Male Vervet
monkeys (Cercopithecus aethiops), 3-6 kg, received kidney allografts and were treated with …
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