Effect of time-out duration on the reinforcing strength of cocaine assessed under a progressive-ratio schedule in rhesus monkeys
JL Martelle, PW Czoty, MA Nader - Behavioural pharmacology, 2008 - journals.lww.com
Progressive-ratio (PR) schedules of reinforcement have provided valuable information
regarding the reinforcing strength of cocaine and the underlying neurobiological
mechanisms. Parametric manipulations, such as altering time-out (TO) values, can affect the
shape of the cocaine dose–response curve. Earlier studies have used PR schedules with
widely varying parameters, thus complicating comparisons across experiments. This study
evaluated the reinforcing strength of cocaine (0.005–0.9 mg/kg) as a function of post …
regarding the reinforcing strength of cocaine and the underlying neurobiological
mechanisms. Parametric manipulations, such as altering time-out (TO) values, can affect the
shape of the cocaine dose–response curve. Earlier studies have used PR schedules with
widely varying parameters, thus complicating comparisons across experiments. This study
evaluated the reinforcing strength of cocaine (0.005–0.9 mg/kg) as a function of post …
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