[HTML][HTML] Effect of xanthone from Kielmeyera coriacea stems on serotonergic neurons of the median raphe nucleus
VR Sela, I Hattanda, CM Albrecht, CB De Almeida… - Phytomedicine, 2010 - Elsevier
Kielmeyera coriacea Mart.(Clusiaceae), known as “Pau Santo”, is used to treat several
tropical diseases. The hydroethanolic extract (HE) of Kielmeyera coriacea stems and its
semi-pure dichloromethane constituent (DCM) produced an anti-immobility effect in rats
submitted to the forced swimming test (FST), suggesting a antidepressant-like profile. This
study evaluated the effect of intra-median raphe nucleus (MRN) microinjection of 1, 3, 7-
trihydroxy-2-(3-methylbut-2-enyl)-xanthone, present in large quantity in the HE from …
tropical diseases. The hydroethanolic extract (HE) of Kielmeyera coriacea stems and its
semi-pure dichloromethane constituent (DCM) produced an anti-immobility effect in rats
submitted to the forced swimming test (FST), suggesting a antidepressant-like profile. This
study evaluated the effect of intra-median raphe nucleus (MRN) microinjection of 1, 3, 7-
trihydroxy-2-(3-methylbut-2-enyl)-xanthone, present in large quantity in the HE from …
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