Effects of comicronised fenofibrate on lipid and insulin sensitivity in patients with polymetabolic syndrome X

B Idzior‐Walus, J Sieradzki… - European journal of …, 2000 - Wiley Online Library
B Idzior‐Walus, J Sieradzki, W Rostworowski, A Zdzienicka, E Kawalec, J Wojcik, A Żarnecki…
European journal of clinical investigation, 2000Wiley Online Library
Background This study investigated the effects of comicronised fenofibrate in patients with
dyslipidemia and polymetabolic syndrome X. Design After a 6‐week dietary run‐in phase,
37 male patients eligible on lipid criteria entered a 12‐week treatment phase consisting of
diet plus one capsule daily containing 200 mg of comicronised fenofibrate (Lipanthyl®).
Results A significant reduction in plasma concentrations of total cholesterol, LDL cholesterol
and triglyceride was observed after 4, 8 and 12 weeks of treatment with fenofibrate. The …
Background
This study investigated the effects of comicronised fenofibrate in patients with dyslipidemia and polymetabolic syndrome X.
Design
After a 6‐week dietary run‐in phase, 37 male patients eligible on lipid criteria entered a 12‐week treatment phase consisting of diet plus one capsule daily containing 200 mg of comicronised fenofibrate (Lipanthyl®).
Results
A significant reduction in plasma concentrations of total cholesterol, LDL cholesterol and triglyceride was observed after 4, 8 and 12 weeks of treatment with fenofibrate. The improvement in the atherogenic index LDL/HDL cholesterol from a pretreatment 3.8 to 3.0 after treatment was highly statistically significant and may be judged as satisfactory. Significant changes were also observed in haemostatic factors (fibrinogen reduced by 19%, factor VII activity reduced by 18%). Fasting serum insulin levels and insulin response (area under the curve) after oral glucose load were significantly reduced by 26.8% and 18.7%, respectively, indicating an improvement of insulin sensitivity. Systolic and diastolic blood pressure were significantly reduced. Uric acid was significantly reduced by 21.6%.
Conclusion
These favourable effects of comicronised fenofibrate both on lipid and non lipid parameters, including insulin sensitivity, may confer to this product a particular interest in the treatment of patients with polymetabolic syndrome X.
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