Effects of rivaroxaban and dabigatran on local expression of coagulation and inflammatory factors within human aortic stenotic valves
E Wypasek, J Natorska, P Mazur, M Kopytek… - Vascular …, 2020 - Elsevier
Background Treatment with non-vitamin K antagonist oral anticoagulants (NOACs) such as
dabigatran (a direct thrombin inhibitor) or rivaroxaban (a direct inhibitor of factor [F] Xa)
attenuates atherosclerotic plaque progression in hypercholesterolemic mice. Purpose: To
evaluate the effect of NOACs application on the expression of coagulation proteins in loco
within stenotic aortic valves and in valve interstitial cells (VICs) from patients with severe
aortic stenosis (AS). Methods Primary cultures of VICs obtained from 90 patients undergoing …
dabigatran (a direct thrombin inhibitor) or rivaroxaban (a direct inhibitor of factor [F] Xa)
attenuates atherosclerotic plaque progression in hypercholesterolemic mice. Purpose: To
evaluate the effect of NOACs application on the expression of coagulation proteins in loco
within stenotic aortic valves and in valve interstitial cells (VICs) from patients with severe
aortic stenosis (AS). Methods Primary cultures of VICs obtained from 90 patients undergoing …
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