[Met5] enkephalin-Arg6-Phe7-and [Met5] enkephalin-Arg6-Gly7-Leu8-immunoreactive nerve fibres and neurons in the superior cervical ganglion of the rat
O Häppölä, S Soinila, H Päivärinta, P Panula - Neuroscience, 1987 - Elsevier
Abstract [Met 5] enkephalin-Arg 6-Phe 7-(MEAP-) and [Met 5] enkephalin-Arg 6-Gly 7-Leu 8-
(MEAGL-) immunoreactivity was studied by indirect immunohistochemistry in the superior
cervical ganglion of the rat with specific antisera produced in rabbits against the
corresponding synthetic opioid peptides. Several MEAP-and a few MEAGL-immunoreactive
principal nerve cells were observed in the ganglion, while the small intensely fluorescent
cells appeared as non-reactive. The superior cervical ganglion also contained dense …
(MEAGL-) immunoreactivity was studied by indirect immunohistochemistry in the superior
cervical ganglion of the rat with specific antisera produced in rabbits against the
corresponding synthetic opioid peptides. Several MEAP-and a few MEAGL-immunoreactive
principal nerve cells were observed in the ganglion, while the small intensely fluorescent
cells appeared as non-reactive. The superior cervical ganglion also contained dense …
EFFECTS OF THE OPIOID PEPTIDES [MET5]ENKEPHALIN‐ARG6‐PHE7 AND [MET5]ENKEPHALIN‐ARG6‐GLY7‐LEU8 ON CHOLINERGIC …
H Wong‐Dusting, MJ Rand - Clinical and experimental …, 1987 - Wiley Online Library
The effect of the opioid peptides [Met5] enkephalin‐Arg6‐Phe7 (MEAP) and [Met5]
enkephalin‐Arg6‐Gly7‐Leu8 (MEAGL) were compared with those of [Leu5] enkephalin and
[d‐Ala2, Met5] enkephalinamide (DAME) on cholinergic neuro‐transmission in the rabbit
isolated atria. 2. Rabbit isolated atria had a resting rate of 190 beats/min. In the presence of
the β‐adrenoceptor antagonist propranolol (0.3 μmol/l), atria responded to electrical field
stimulation with a cholinergically mediated negative chronotropic response. The opioid …
enkephalin‐Arg6‐Gly7‐Leu8 (MEAGL) were compared with those of [Leu5] enkephalin and
[d‐Ala2, Met5] enkephalinamide (DAME) on cholinergic neuro‐transmission in the rabbit
isolated atria. 2. Rabbit isolated atria had a resting rate of 190 beats/min. In the presence of
the β‐adrenoceptor antagonist propranolol (0.3 μmol/l), atria responded to electrical field
stimulation with a cholinergically mediated negative chronotropic response. The opioid …
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