In this work, we develop methodologies for analyzing and cross comparing metabolic
models. We investigate three important metabolic networks to discuss the complexity of
biological organization of organisms, modeling, and system properties. In particular, we
analyze these metabolic networks because of their biotechnological and basic science
importance: the photosynthetic carbon metabolism in a general leaf, the Rhodobacter
spheroides bacterium, and the Chlamydomonas reinhardtii alga. We adopt single-and multi …

Figure 1: Results obtained by Sensitivity and Optimization for aspartate metabolism in
plants.(A) Morris sensitivity results performed on the aspartate metabolism.(B) The ratio
between the optimized concentrations obtained with maximum and minimum aspartate with
respect to the original concentrations. The red line represents an equal concentration after
the optimization, that is concentrations ratio equal to one.