Elevation of intracellular Zn2+ level by nanomolar concentrations of triclocarban in rat thymocytes
J Morita, A Teramachi, Y Sanagawa, S Toyson… - Toxicology letters, 2012 - Elsevier
It was recently reported that nanomolar concentrations of triclocarban, an antimicrobial
agent, were detected in human blood after the use of soap containing triclocarban. Due to
the widespread use of triclocarban in adult and infant personal care products, the report
prompted us to study its cytotoxicity. The cytotoxicity of triclocarban was examined in rat
thymocytes by using a cytometric technique with propidium iodide for examining cell
lethality, FluoZin-3-AM for monitoring the intracellular Zn2+ level, and 5 …
agent, were detected in human blood after the use of soap containing triclocarban. Due to
the widespread use of triclocarban in adult and infant personal care products, the report
prompted us to study its cytotoxicity. The cytotoxicity of triclocarban was examined in rat
thymocytes by using a cytometric technique with propidium iodide for examining cell
lethality, FluoZin-3-AM for monitoring the intracellular Zn2+ level, and 5 …
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