Enriched immune-environment of blood–brain barrier deficient areas of normal adult rats

EB Pedersen, JA McNulty, AJ Castro, LM Fox… - Journal of …, 1997 - Elsevier
The circumventricular organs (CVOs) in the brain are without a blood–brain barrier (BBB)
and as such directly exposed to blood plasma constituents and blood-borne pathogens. In
light of previous studies showing discrepancies regarding the immunocompetence of these
organs, we initiated the present study to provide a comprehensive immunohistochemical
analysis of the cellular expression of immune-associated antigens within the pineal gland,
area postrema and the subfornical organ. In all CVOs, subpopulations of cells …
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