… reevaluate estrogens for their ability to activate human PXR, we assayed estrogenic compounds
with two HeLa-derived reporter cell lines, the HGPXR cells, which detect hPXR ligands, …

… sulfation, because sulfonated estrogens cannot bind to and activate ER, thus losing their …
Therefore hPXR activation would tip the hepatocellular androgen/estrogen balance toward …

… , activated hPXR by 26.6% and 17%, respectively. The pesticide trans-nonachlor activation
… Quercetin is believed to have a potent inhibitory effect upon estrogen sulfotransferase (EST)…

… antagonists or partial agonists of estrogen receptors, which are … antiestrogens activate
hPXR. In general, there was good agreement between the CYP3A4 induction and hPXR activation…

… In order to understand the role of ligand in receptor activation molecular models of the
ERβ, hPXR, AhR and hCAR LBDs have been generated from a ligand bound hERα crystal …

… activate one or both receptors, including several endocrine disrupting chemicals. Environmental
estrogens, such … activate either PXR or both PXR and CAR. Because PXR and CAR are …

… of estrogens is … -activated TF that regulates transcription of estrogen-responsive genes in
the cell nucleus [6]. However, ESR1 can also become activated in the absence of estrogen by …

… DNA sequence of the ERE, and transactivates gene expression in response to estrogens [60,
61]. Al… provides an explanation for their antiestrogenic properties, increased metabolism of …

… This is in contrast to the steroid nuclear receptors, the estrogen … (B) Crystal structure of the
ligand binding domain of hPXR (… This is important to prevent ER and GR from being activated …

… Disruption of the position of the terminal helix 12 in the LBD of the estrogen and estrogen-related
receptors is the molecular basis for the … Estrogens and antiestrogens activate hPXR. …