Evaluation of Th17-related cytokines and receptors in multiple sclerosis patients under interferon beta-1 therapy
G Esendagli, AT Kurne, G Sayat, AK Kilic, D Guc… - Journal of …, 2013 - Elsevier
Th17-related cytokines (IL-17, IL-23, and IL-26) and receptors (IL-17R and IL-23R) were
evaluated in MS patients under immunomodulatory IFN-β1 therapy during a 2year follow-up.
Before the initiation of treatment, no significant difference was found in cytokine or receptor
expression between controls and MS patients. Of the three cytokines evaluated, IL-26 was
the highest in the patients' sera. The amount of IL-17 and CD13+ IL-17R+ cells was steadily
decreased whereas IL-23 and IL-26 levels were gradually increased with IFN-β1 therapy …
evaluated in MS patients under immunomodulatory IFN-β1 therapy during a 2year follow-up.
Before the initiation of treatment, no significant difference was found in cytokine or receptor
expression between controls and MS patients. Of the three cytokines evaluated, IL-26 was
the highest in the patients' sera. The amount of IL-17 and CD13+ IL-17R+ cells was steadily
decreased whereas IL-23 and IL-26 levels were gradually increased with IFN-β1 therapy …
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