… We propose that the evolutionary changes that expanded the association cortices and
allowed the generation of sustained mental representations underlying abstract thought confer …

… Viewing AD from an evolutionary perspective prompts a rethinking of the way we describe
the relationship between the clinical dementia and the neuropathology by which we define the …

… as risk factors for neuropathology – to be environmental cues … This article will suggest that
certain, human neuropathological … The forms of congenital neuropathology discussed in this …

… The evolutionary process of the AD-related lesions has been divided artificially into six
NFT/NT stages [13–15] and it has been estimated that the duration of a single NFT/NT stage is …

This paper will suggest that the Down syndrome phenotype would have been well suited,
physiologically, for a deprived environment and that it may represent a predictive, adaptive …

… Approaching the disease from an evolutionary standpoint may help in … This vulnerability
may have resulted from the evolutionary … Neuropathology and apolipoprotein E profile of aged …

… By uniting approaches from comparative neuroanatomy and neuropathology, insights can
be gained that clarify trends in human evolution. Here, we explore these lines of evidence and …

… While humans exhibit a significant degree of neuropathological changes associated with …
age-related and Alzheimer's disease-like neuropathology has been characterized in additional …

Objective: To introduce and discuss an evolutionary model of frontal lobe functioning (the
dual cytoarchitectonic trends theory [DTT]) and its application to understanding the …

… , cell layers, morphogenesis, and evolutionary trajectories of the mammalian nervous system.
… neurophysiological research, or focused on evolutionary outliers or representative species. …