Expression changes of growth-associated protein-43 (GAP-43) and mitogen-activated protein kinase phosphatase-1 (MKP-1) and in hippocampus of streptozotocin …

J Zhou, L Wang, S Ling, X Zhang - Experimental neurology, 2007 - Elsevier
Diabetes mellitus (DM) may give rise to cognitive impairment, but the pathological
mechanism involved was still unknown. We employed streptozotocin (STZ)-induced diabetic
rats and test their capacity for learning and memory by three-arm radial maze. We
determined the expression level of growth-associated protein-43 (GAP-43) and mitogen
activated protein kinase phosphatase-1 (MKP-1) in the hippocampus by
immunohistochemistry. MKP-1 mRNA level in the CA1 and dentate gyrus (DG) Hippocampal …
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