[PDF][PDF] FGF9, activin and TGFbeta promote testicular characteristics in an XX gonad organ culture model
SE Gustin, JM Stringer, K Hogg, AH Sinclair… - Reproduction, 2016 - academia.edu
SE Gustin, JM Stringer, K Hogg, AH Sinclair, PS Western
Reproduction, 2016•academia.edu… We therefore examined the combined ability of FGF9, activin and TGFβ to promote testis
development in XX gonads using an established gonad organ culture system. … Consistent
with this, this study demonstrated that ex vivo exposure of XX gonads to FGF9 promoted
changes in XX gonad characteristic of the developing testis, including supporting cell
proliferation, repression of ovarian genes and promotion of male germ line development.
However, FGF9 alone was insufficient to drive Sox9 transcription or the formation of laminin-delineated …
development in XX gonads using an established gonad organ culture system. … Consistent
with this, this study demonstrated that ex vivo exposure of XX gonads to FGF9 promoted
changes in XX gonad characteristic of the developing testis, including supporting cell
proliferation, repression of ovarian genes and promotion of male germ line development.
However, FGF9 alone was insufficient to drive Sox9 transcription or the formation of laminin-delineated …
Abstract
Testis development is dependent on the key sex-determining factors SRY and SOX9, which activate the essential ligand FGF9.
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