Factors Associated with Immunoglobulin G Subclass Polarization in Naturally Acquired Antibodies to Plasmodium falciparum Merozoite Surface Proteins: a Cross …
KKG Scopel, CJF Fontes, MU Ferreira… - Clinical and vaccine …, 2006 - Am Soc Microbiol
Clinical and vaccine immunology, 2006•Am Soc Microbiol
We investigated immunoglobulin G (IgG) subclass antibody responses to Plasmodium
falciparum merozoite surface protein 1 (MSP-1) and MSP-2 in 112 malaria-exposed subjects
in Brazil. IgG3 polarization was primarily epitope driven, being little affected by cumulative or
current exposure to malaria and not affected by a subject's age and Fcγ receptor IIA
genotype.
falciparum merozoite surface protein 1 (MSP-1) and MSP-2 in 112 malaria-exposed subjects
in Brazil. IgG3 polarization was primarily epitope driven, being little affected by cumulative or
current exposure to malaria and not affected by a subject's age and Fcγ receptor IIA
genotype.
Abstract
We investigated immunoglobulin G (IgG) subclass antibody responses to Plasmodium falciparum merozoite surface protein 1 (MSP-1) and MSP-2 in 112 malaria-exposed subjects in Brazil. IgG3 polarization was primarily epitope driven, being little affected by cumulative or current exposure to malaria and not affected by a subject's age and Fcγ receptor IIA genotype.
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