Fetal mouse alveolar type II cells in culture express several type II cell characteristics found in vivo, together with major histocompatibility antigens
L Oomen, AAW Ten Have-Opbroek… - American Journal of …, 2012 - atsjournals.org
Alveolar type II cells were isolated from fetal mouse lung by differential adherence and
obtained in monolayer culture. Cultures display a high degree of purity as shown by
histochemical and immunocytochemical staining procedures. Seventy-five percent of cells
stained positive with specific anti-lavage serum mouse (SALS-M), an antiserum specific for
(pre) alveolar type II cells of the mouse, and osmiophilic bodies were present in 82% of cells.
These and other characteristics of type II cells in culture correspond to those of alveolar type …
obtained in monolayer culture. Cultures display a high degree of purity as shown by
histochemical and immunocytochemical staining procedures. Seventy-five percent of cells
stained positive with specific anti-lavage serum mouse (SALS-M), an antiserum specific for
(pre) alveolar type II cells of the mouse, and osmiophilic bodies were present in 82% of cells.
These and other characteristics of type II cells in culture correspond to those of alveolar type …
Fetal Mouse Alveolar Type IT Cells in Culture Express Several Type IT Cell Characteristics Found In Vivo, Together with Major Histocompatibility Antigens
MA van der Valk, J Calafat, P Demant - Am. J. Respir. Cell Mol. BioI …, 1990 - atsjournals.org
Alveolar type II cells produce lung surfactant, which prevents collapse of the peripheral air
spaces at expiration. The production of lung surfactant is an essential step in fetal
maturation, and deficient surfactant production results in a serious clinical syndrome in
neonates and young children (reviewed in reference 1). Studies on the regulation of
differentiation and surfactant synthesis in fetal lung led to the unravelling of a complex
network of regulatory factors, in-
spaces at expiration. The production of lung surfactant is an essential step in fetal
maturation, and deficient surfactant production results in a serious clinical syndrome in
neonates and young children (reviewed in reference 1). Studies on the regulation of
differentiation and surfactant synthesis in fetal lung led to the unravelling of a complex
network of regulatory factors, in-
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