Fetuin mediates hepatic uptake of negatively charged nanoparticles via scavenger receptor

S Nagayama, K Ogawara, K Minato, Y Fukuoka… - International journal of …, 2007 - Elsevier
We tried to evaluate the possible involvement of fetuin in the scavenger receptors (SRs)-
mediated hepatic uptake of polystyrene nanospheres with the size of 50nm (NS-50), which
has surface negative charge (zeta potential=− 21.8±2.3 mV). The liver perfusion studies in
rats revealed that the hepatic uptake of NS-50 pre-coated with fetuin (NS-50-fetuin) was
significantly inhibited by poly inosinic acid (poly I), a typical inhibitor of SRs, whereas that of
plain NS-50 or NS-50 pre-coated with BSA (NS-50-BSA) was not. The uptake of NS-50 …
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