Flow-function dissociation following an acute dose of cocaine: effect of captopril on coronary flow
S Rezkalla, S Hale, K Alker, RA Kloner - Coronary Artery Disease, 1993 - journals.lww.com
Background: Acute administration of cocaine leads to left ventricular dysfunction and a
decrease in coronary blood flow. This experiment studied the relationship between function
and flow over time in cocaine heart disease and examined the effects of captopril on this
relationship. Methods: Dogs anesthetized with pentobarbital (n= 13) were given a 3 mg/kg
body weight intravenous bolus of cocaine followed by a 7 mg/kg infusion over 10 minutes.
Animals were then randomly assigned to receive either captopril (0.5 mg/kg infused over 5 …
decrease in coronary blood flow. This experiment studied the relationship between function
and flow over time in cocaine heart disease and examined the effects of captopril on this
relationship. Methods: Dogs anesthetized with pentobarbital (n= 13) were given a 3 mg/kg
body weight intravenous bolus of cocaine followed by a 7 mg/kg infusion over 10 minutes.
Animals were then randomly assigned to receive either captopril (0.5 mg/kg infused over 5 …
