Fluorine-19 NMR of integral membrane proteins illustrated with studies of GPCRs
Highlights•Renewed interest in 19 F NMR for structural biology of complex molecular
systems.•Advances in biochemistry and NMR techniques enable 19 F NMR studies of new
classes of membrane proteins.•19 F NMR of GPCRs complements crystal structures with
data on protein dynamics in long-range signal transfer.Fluorine-19 is a spin-½ NMR isotope
with high sensitivity and large chemical shift dispersion, which makes it attractive for high
resolution NMR spectroscopy in solution. For studies of membrane proteins it is further of …
systems.•Advances in biochemistry and NMR techniques enable 19 F NMR studies of new
classes of membrane proteins.•19 F NMR of GPCRs complements crystal structures with
data on protein dynamics in long-range signal transfer.Fluorine-19 is a spin-½ NMR isotope
with high sensitivity and large chemical shift dispersion, which makes it attractive for high
resolution NMR spectroscopy in solution. For studies of membrane proteins it is further of …
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