Follicular expression of pro-inflammatory cytokines tumour necrosis factor-α (TNFα), interleukin 6 (IL6) and their receptors in cattle: TNFα, IL6 and macrophages …

MS Samir, C Glister, D Mattar, M Laird… - Reproduction, 2017 - centaur.reading.ac.uk
Pro-inflammatory cytokines secreted by macrophages and other cell-types are implicated as
intra-ovarian factors affecting different aspects of ovarian function including follicle and
corpus luteum'turnover', steroidogenesis and angiogenesis. Here, we compared granulosal
(GC) and thecal (TC) expression of TNF, IL6 and their receptors (TNFR1, TNFRSF1B, IL6R)
during bovine antral follicle development; all five mRNA transcripts were detected in both
GC and TC and statistically significant cell-type and follicle stage-related differences were …
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