From anti-Parkinson's drug rasagiline to novel multitarget iron chelators with acetylcholinesterase and monoamine oxidase inhibitory and neuroprotective properties …
Alzheimer's disease (AD) is a multifactorial syndrome involving a complex array of different,
while related, factors in its progression. Accordingly, novel approaches that can
simultaneously modulate several disease-related targets hold great promise for the effective
treatment of AD. This review describes the development of novel hybrid molecules with
multimodal activity, including: i) M30, the brain permeable selective monoamine oxidase
(MAO)-A and-B inhibitor with chelating and neuroprotective activity; ii) HLA20, a brain …
while related, factors in its progression. Accordingly, novel approaches that can
simultaneously modulate several disease-related targets hold great promise for the effective
treatment of AD. This review describes the development of novel hybrid molecules with
multimodal activity, including: i) M30, the brain permeable selective monoamine oxidase
(MAO)-A and-B inhibitor with chelating and neuroprotective activity; ii) HLA20, a brain …
From Anti-Parkinson's Drug Rasagiline to Novel Multitarget Iron Chelators with Acetylcholinesterase and Monoamine Oxidase Inhibitory and Neuroprotective …
Alzheimer's disease (AD) is a multifactorial syndrome involving a complex array of different,
while related factors in its progression. Accordingly, novel approaches that can
simultaneously modulate several disease-related targets hold great promise for the effective
treatment of AD. This review describes the development of novel multimodal compounds, as
follows: the brain selective monoamine oxidase (MAO)-A and-B inhibitor with chelating and
neuroprotective activity, M30; the chelating with neuroprotective activity, HLA20; the …
while related factors in its progression. Accordingly, novel approaches that can
simultaneously modulate several disease-related targets hold great promise for the effective
treatment of AD. This review describes the development of novel multimodal compounds, as
follows: the brain selective monoamine oxidase (MAO)-A and-B inhibitor with chelating and
neuroprotective activity, M30; the chelating with neuroprotective activity, HLA20; the …
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