Functional activity of neutrophils in diabetes mellitus and coronary heart disease: role of myeloperoxidase in the development of oxidative stress

IV Gorudko, VA Kostevich, AV Sokolov… - Bulletin of Experimental …, 2012 - Springer
IV Gorudko, VA Kostevich, AV Sokolov, EV Shamova, IV Buko, EE Konstantinova…
Bulletin of Experimental Biology and Medicine, 2012Springer
We performed a comparative analysis of functional activity of neutrophils in patients with
type 2 diabetes mellitus with and without symptoms of CHD. Enhanced H 2 O 2 production
by neutrophils in response to N-formyl-Met-Leu-Phe (fMLP) was found in patients with type 2
diabetes mellitus. In patients with type 2 diabetes mellitus associated with CHD, fML-
Pinduced release of myeloperoxidase from azurophilic granules of neutrophils was reduced
and plasma myeloperoxidase level was elevated. Increased peroxidase activity of …
We performed a comparative analysis of functional activity of neutrophils in patients with type 2 diabetes mellitus with and without symptoms of CHD. Enhanced H2O2 production by neutrophils in response to N-formyl-Met-Leu-Phe (fMLP) was found in patients with type 2 diabetes mellitus. In patients with type 2 diabetes mellitus associated with CHD, fML-Pinduced release of myeloperoxidase from azurophilic granules of neutrophils was reduced and plasma myeloperoxidase level was elevated. Increased peroxidase activity of myeloperoxidase, reduced plasma catalase activity, and increased levels of TBA-reactive lipid peroxidation products and oxidized glutathione were detected in patients of both groups. Since myeloperoxidase is an important neutrophilic mediator of oxidative stress, its increased activity in the blood can be an additional marker of oxidative stress and cardiovascular risk in patients with diabetes mellitus.
Springer
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