Functional cloning of Vibrio parahaemolyticus type III secretion system 1 in Escherichia coli K-12 strain as a molecular syringe
Y Akeda, T Kimura, A Yamasaki, T Kodama… - Biochemical and …, 2012 - Elsevier
The type III secretion system (T3SS) of gram-negative bacteria involves dedicated protein
translocation machinery that directly injects proteins into target cells. Pathogenic bacteria
already benefit from this unique system. The successful functional cloning of this useful tool
into non-pathogenic bacteria would help establish novel clinical and basic biotechnology
strategies in areas such as vaccine administration, the development of screening systems
for anti-T3SS drugs and the target-specific delivery of bioactive compounds. In this study, we …
translocation machinery that directly injects proteins into target cells. Pathogenic bacteria
already benefit from this unique system. The successful functional cloning of this useful tool
into non-pathogenic bacteria would help establish novel clinical and basic biotechnology
strategies in areas such as vaccine administration, the development of screening systems
for anti-T3SS drugs and the target-specific delivery of bioactive compounds. In this study, we …
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