Gene expression analysis of multiple gastrointestinal regions reveals activation of common cell regulatory pathways following cytotoxic chemotherapy
Gastrointestinal mucositis involves many changes at the gene level, affecting
epithelial/subepithelial interactions and leading to overt damage. The regional specificity
and time course of these changes, and how they relate to subsequent mucositis
development however remain unknown. The aim of this study was to determine the early
time course of gene expression changes along the gastrointestinal tract of the DA rat
following chemotherapy. Female DA rats were treated with a single dose of 200 mg/kg …
epithelial/subepithelial interactions and leading to overt damage. The regional specificity
and time course of these changes, and how they relate to subsequent mucositis
development however remain unknown. The aim of this study was to determine the early
time course of gene expression changes along the gastrointestinal tract of the DA rat
following chemotherapy. Female DA rats were treated with a single dose of 200 mg/kg …
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