[HTML][HTML] Gene therapy for overexpressing Neuregulin 1 type I in skeletal muscles promotes functional improvement in the SOD1G93A ALS mice
G Mòdol-Caballero, M Herrando-Grabulosa… - Neurobiology of …, 2020 - Elsevier
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder affecting motoneurons
(MNs), with no effective treatment currently available. The molecular mechanisms that are
involved in MN death are complex and not fully understood, with partial contributions of
surrounding glial cells and skeletal muscle to the disease. Neuregulin 1 (NRG1) is a trophic
factor highly expressed in MNs and neuromuscular junctions. Recent studies have
suggested a crucial role of the isoform I (NRG1-I) in the collateral reinnervation process in …
(MNs), with no effective treatment currently available. The molecular mechanisms that are
involved in MN death are complex and not fully understood, with partial contributions of
surrounding glial cells and skeletal muscle to the disease. Neuregulin 1 (NRG1) is a trophic
factor highly expressed in MNs and neuromuscular junctions. Recent studies have
suggested a crucial role of the isoform I (NRG1-I) in the collateral reinnervation process in …
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