[HTML][HTML] Genetic determinants of normal variation in coagulation factor (F) IX levels: genome‐wide scan and examination of the FIX structural gene
Background: High‐normal and elevated plasma FIX activity (FIX: C) levels are associated
with increased risk for venous‐and possibly arterial‐thrombosis. Objective: Because the
broad normal range for FIX: C involves a substantial unknown genetic component, we
sought to identify quantitative‐trait loci (QTLs) for this medically important hemostasis trait.
Methods: We performed a genome‐wide screen and a resequencing‐based variation scan
of the known functional regions of every distinct FIX gene (F9) in the genetic analysis of …
with increased risk for venous‐and possibly arterial‐thrombosis. Objective: Because the
broad normal range for FIX: C involves a substantial unknown genetic component, we
sought to identify quantitative‐trait loci (QTLs) for this medically important hemostasis trait.
Methods: We performed a genome‐wide screen and a resequencing‐based variation scan
of the known functional regions of every distinct FIX gene (F9) in the genetic analysis of …
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