Glycolytic metabolism confers resistance to combined all-trans retinoic acid and arsenic trioxide-induced apoptosis in HL60ρ0 cells
PM Herst, EL Hesketh, DS Ritchie, MV Berridge - Leukemia research, 2008 - Elsevier
Glycolytic cancers are resistant to many forms of chemotherapy and some respond poorly to
differentiation therapies. Here, we investigate the effects of exposure to all-trans retinoic acid
(ATRA) and arsenic trioxide (ATO) on differentiation and cell survival in the human leukemia
cell line, HL60 and its mitochondrial gene knockout mutant, HL60ρ0. Glycolytic HL60ρ0 cells
exposed to single and combined treatments expressed less CD15, in most cases, but
produced a stronger respiratory burst than parental HL60 cells. HL60ρ0 cells were also …
differentiation therapies. Here, we investigate the effects of exposure to all-trans retinoic acid
(ATRA) and arsenic trioxide (ATO) on differentiation and cell survival in the human leukemia
cell line, HL60 and its mitochondrial gene knockout mutant, HL60ρ0. Glycolytic HL60ρ0 cells
exposed to single and combined treatments expressed less CD15, in most cases, but
produced a stronger respiratory burst than parental HL60 cells. HL60ρ0 cells were also …
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