We would like to report our recent experience dealing with a 2-year-old boy with Saccharomyces cerevisiae fungaemia. The toddler was presented with high fever and profound diarrhoea. He was prescribed antibiotics for presumed bacterial dysentery and probiotics containing Saccharomyces boulardi. Stool cultures were negative for Salmonella, Shigella, Yersinia and Campylobacter. Two days later due to persistent fever and diarrhoea, blood tests including blood cultures were taken. Two sets of blood cultures following 48 h of incubation grew S. cerevisiae resistant to fluconazole. The child was then admitted to the hospital for detailed evaluation and started antifungal treatment. Inpatient investigations included abdominal ultrasound (liver, spleen and kidneys) and cardiac echocardiogram and did not reveal any evidence of fungal dissemination. Extensive evaluations yielded no evidence of immunodeficiency. He completed a 2-week course of micafungin based on the antifungigram of the isolated agent with good clinical response. One of the most commonly used fungi in probiotics is