HIV mucosal vaccine: nasal immunization with rBCG-V3J1 induces a long term V3J1 peptide-specific neutralizing immunity in Th1-and Th2-deficient conditions

T Hiroi, H Goto, K Someya, M Yanagita… - The Journal of …, 2001 - journals.aai.org
In the vaccine strategy against HIV, bacillus Calmette-Guérin (BCG), a live attenuated strain
of Mycobacterium bovis, is considered to be one of potential vectors for mucosal delivery of
vaccine Ag. We analyzed the induction of the Ag-specific Ab response by nasal
immunization with recombinant BCG vector-based vaccine (rBCG-V3J1) that can secrete the
V3 principal neutralizing epitope of HIV. Mice were nasally immunized with rBCG-V3J1 (10
μg) three times at weekly intervals. Four weeks after the initial immunization, high titers of …

HIV mucosal vaccine: nasal immunization with rBCG-V3J1 induces a long-term V3J1 peptide-specific neutralizing immunity in Th1-and Th2-deficient condition

H Goto, T Hiroi, M Ynagita, N Yamanaka… - International Congress …, 2003 - Elsevier
In the vaccine strategy against HIV, the bacillus Calmette–Guerin (BCG), a live attenuated
strain of Mycobacterium bovis, is considered to be one of the potential vectors for mucosal
delivery of antigens. We analyzed the induction of antigen-specific antibodies by nasal
immunization with recombinant BCG vector-based vaccine (rBCG-V3J1) that secretes the V3
principal neutralizing epitope of HIV [Proc. Natl. Acad. Sci. USA 92 (1063) 1995]. C57BL/6
mice were nasally immunized with the rBCG-V3J1 (10 μg) four times by weekly intervals …
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