HIV-negative Men Who Have Sex with Men have higher CD8+ T-cell Counts and Lower CD4+/CD8+ T-cell Ratios compared to HIV-negative Heterosexual Men

SO Verboeket, FW Wit, E Verheij, RA van Zoest… - J Infect Dis, 2020 - hero.epa.gov
We reported T-cell senescence to be similar in people living with HIV (PWH) with
suppressed viremia (predominantly men who have sex with men (MSM)) and HIV-negative
otherwise comparable controls, but greater than in healthy blood donors. This lead us to
compare CD4+ and CD8+ T-cell counts and CD4+/CD8+ ratios between HIV-negative MSM
and men who only have sex with women (MSW), and relate observed differences to
behavioral factors and infectious exposures, including cytomegalovirus (CMV) infection.
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