Our knowledge of the mechanisms underlying tumor-specific immune response and tumor
escape has considerably increased. HLA class I antigen defects remain an important tumor
escape mechanism since they influence the interactions between tumor cells and specific T
and NK cells in the course of malignant disease. We have studied here HLA class I
expression in six subcutaneous metastases obtained from a melanoma patient immunized
with an autologous melanoma cell vaccine (M-VAX). We report in this paper that HLA class I …